Andriol profile

Andriol is testosterone undecanoate ester attached with and produced in oral form. It represents the first real attempt to create an oral testosterone since Methyl testosterone. I can only assume that the scientists responsible for this wanted to create a viable alternative to both injectable testosterones (which, at least for hormone replacement therapy, is inconvenient), as well as other oral forms of testosterone (which have always been very harsh on the liver). What they came up with turned out to be a very odd steroid in many ways


To create Andriol, the scientists involved had to find a solution to methyltestosterone, namely the fact that it is hard on the liver and should be taken in very high doses to produce decent results. What they did was put 40mgs of testosterone undecanoate in oleic acid (an oil), and encapsulate. Now they use castor oil and propylene glycol laurate instead of oleic acid, but this only increases the life, and does nothing else. For some of the aspiring chemists reading this, you may ask the obvious question. And the answer is yes, you can take any medication estrified (nandrolone, for example), and dissolve it in castor oil and glycol laurate propelyne and create your own "Deca Caps" or whatever. The problem is that you'd need to be able to make sealed gel caps, not just the typical 2-part capsules most people throw steroid powder in. Anyway, Im digression; back to Andriol. After you put some testosterone undecanoate in castor oil and glycol laurate propelyne, youll have a testosterone which is highly fat-soluble due to the (very large) undecanoate ester attached to it, and capable of being absorbed by the small intestine via the lymphatic system. What this means is that it avoids the "first pass" through the liver, a process which could destroy much of the active steroid, and place an excessive amount of stress on the liver. He also displayed a rapid absorption and turnover in one study (11), which may explain its ability to not cause unwanted side effects. This is not bad for your blood pressure (13), and also has no adverse effects on the prostate and may even improve blood pressure (12)! Thus, Andriol is remarkably light on all side effects, especially those related to liver toxicity and estrogenic sides.

Andriol for Women
In this study, with women, it even displayed no ability to lower LH and FSH (luteinizing hormone and follicle-stimulating hormone, respectively), which are the hormones that tell your body to make more testosterone (11) . I doubt Andriol could be properly regarded as liver toxic or too damaging to your HPTA (Hypothalamic-Pituitary-Testicular-Axis, the thing that governs your body's production of testosterone, among others). any type of reasonable dose (or excessive). In fact, a study has no adverse reactions or effects at all with the use of Andriol (10). As for your lipid profile and cholesterol, it has even been shown to have beneficial effects on (14)!

So put some testosterone undecanoate in Gel Capsules is what scientists at Organon have done with their Andriol product, and everything looks good so far, right? The active steroid totally bypasses your liver and hence does not get damaged by or damage your liver, and gets a lot of testosterone in your body. Super! But what happens next? Well, after the lymphatic system has brought the testosterone undecanoate into circulation in your body, the undecanoate ester begins to be removed. That leaves you with (approximately) 25mgs of testosterone into the bloodstream, as decanoate ester takes a lot of "space" and the cap only contains a total of 40mgs of testosterone undecanoate (about 15mgs are ester). The final results of Andriol would be very similar to the result of the injection of almost any form of testosterone (4), once your body removes the ester end. But remember, you'd never inject 25mgs of testosterone suspension and call it a day, but that's exactly what you do when you take one Andriol cap.

So now you have 25mgs of testosterone floating around in your body. This is not much, so if you're into realistic to use this product, you will need to take a few caps of this it. And theres one of the first problems we encounter with this drug. You see, the mode of administration of this drug product offers a liver safety well, but this stuff will peak your testosterone levels within approximately 2 hours after administration, and will remain (at least slightly ) elevated for 10 hours or more (1). Ideally, you'd be taking a capsule every 2 hours, which is inconvenient to say the least. Lets be generous and say that you can just take one every 4 hours. Problem solved? Not really, because we will need to take at least 2 caps with each dose if we want any kind of anabolic effect, and if it is taken every 4 hours (assuming were awake for 16hrs every day), then well take around 8 capsules per day. Now we've shifted the problem away from the effort to take effective being a problem with the economy.

Purchase cost Andriol
The problem with type of dose will be cost to buy andriol. Andriol is pretty expensive to taking charge of 8 capsules per day, and I've never seen by anyone except for Organon and that means that we do not find the product underground laboratories lists. And that means we have to pay the price Organon request ... and they ask a lot. You can easily run a cycle of several very anabolic compounds for the price of a cycle of Andriol only.

So this is our main obstacle, the expense of taking Andriol in what would be an effective dose is prohibitive for most people. One study noted that Andriol therapy, when compared with traditional Testosterone injections is roughly 7-8x more expensive (5).

Side effects Andriol
Cost not withstanding, lets see what kind of Andriol side effects we can expect (besides the catabolic effect it will have on your wallet). Although it has a reputation for being very soft, you will still see some results from Andriol. A study using a very low dose on adolescent boys still showed a reasonable gain lean body mass (3), even if the boys were not training. And in another study of elderly, it improved their quality of life considerably (as androgens often do) (6), and also had beneficial effects on erectile dysfunction (7) (again, this is typical androgen). This is certainly promising, but in a world where first time-ste In fact, it may even be a useful adjunct with Viagra for this purpose (8). However, in a world where first time steroid users expect upwards of £ 20 per cycle, I suspect many will be disappointed with the £ 5 or so a cycle of Andriol will produce. Certainly, that's a conservative estimate, but I can not really be confident predicting much more muscle is to be expected from Andriol. Taking a large amount of Andriol is actually pretty safe (except for your bank account), and there was even a 3 month study done in Korea, where a pretty small dose of Andriol (160 mg daily for 3 weeks then half this dose for the remainder of the study) resulted in a great increase of testosterone. Total serum testosterone increased from 2.13 + / - 1.20 ng / ml at baseline to 6.04 + / - 3.08 ng / ml (p = 0.005) after 12 weeks. In addition, free testosterone was (barely) significantly changed from 8.60 + / - 2.25 pg / ml to 11.40 + / - 3.81 pg / ml (p = 0.13) (10). However, there were no significant changes in liver function tests, red blood cell count or lipid profiles, nor that there were significant side effects that led to discontinuation of the administration of testosterone orally. Thus, scientists Organon have succeeded in making a beautiful course oral treatment, moderately effective for the low androgen levels. But can we (athletes and bodybuilders) use it also?

Actually, I can not be sure of predicting more than a 5lbs gain with the use of Andriol, because this product has a very strange property, and that it is very different effects it has on test subjects. In one study I read, four test subjects were each given Andriol, and one had a huge increase testosterone levels up 60.1nmol / L and the other only had a standard (5) 11.5nmol / L! The two remaining test subjects fell between these levels. I am speculating that the differences experienced by the test subjects is mainly due to inherent variations in the lymphatic system. But to make things even more inconsistent, there is no evidence that these differences would not occur within the same person who Andriol (you get a huge increase in testosterone one day, and a very minor the next day) . This may be due to the variability associated with whether this stuff is taken with or without food. Since it operates via association with your small intestine and lymphatic pathways, take it with food greatly increases its bioavailability (9), and this may be a case of "problem solved" but I'm hesitant to close the books on problems andriols absorption so fast, for the moment, although you just spend your money more wisely if you take your andriol with meals.

Despite all its problems, if I had the money to run 10-15 caps of Andriol / day, and if I want a standalone oral compound to safely run for a full cycle (maybe 12 weeks) then I have to admit, Andriol would be my # 1 choice.

Testosterone undecanoate and may offer an alternative for androgen treatment in women.

Testosterone undecanoate ester +
[Androsta-4-en-3-one, 17b-ol]
Molecular weight of base: 288.429
Molecular weight of the ester: 186.2936
Formula: C19 H28 O2
Melting point: 155
Manufacturer: Organon
Effective Dose: 600mgs
Active Life: less than 8-12 hours
Detection Time: 4-5 weeks
Ratio anabolic / androgenic (Range): 100:100

References:

That androgen replacement therapy for women? Journal of Clin Endocrinol Metab and. 83 1998 3920 -24
A new formulation of oral testosterone undecanoate. J Urol World. November 2003, 21 (5) :311-5. Epub 2003 October 25 Reviews.
Effects of oral testosterone undecanoate on growth, body composition, strength and energy expenditure of adolescents. Clin Endocrinol (Oxf). September 1992; 37 (3) :207-13.
Recovery of free androgens in the rat prostate in vivo and in vitro after treatment with testosterone undecanoate active orally (TU). Horm Metab Res. 1980 OCT; 12 (10) :541-5
That therapy testosterone replacement? Clin Endocrinol (OXF) 21 198497-107
Effect of oral testosterone undecanoate on visuospatial cognition, mood and quality of life in older men with low-normal gonadal status. Maturitas. 14 February 2005; 50 (2) :124-33.
Effect 12 months oral testosterone on testosterone deficiency symptoms in symptomatic elderly men with low-normal gonadal status. Age aging. March 2005; 34 (2) :125-30. Epub 2004 December 13.
Testosterone undecanoate orally reverses erectile dysfunction associated with diabetes mellitus in patients failing treatment with sildenafil citrate alone. Aging Male. June 2003; 6 (2) :94-9.
Important effect of food on the bioavailability of oral testosterone undecanoate. Pharmacotherapy. March 2003; 23 (3) :319-25.
Testosterone replacement orally in Korean patients with PADAM. Aging Male. 2002 Jun; 5 (1) :52-6.
Administration of testosterone undecanoate in postmenopausal women: effects on androgens, estradiol, and gonadotropins. Menopause. 2000 Jul-Aug; 7 (4) :251-6.
Effects of supplementation therapy on partial androgen androgen deficiency in aging men: a preliminary study. Aging Male. 2002 Jun; 5 (1) :47-51.
The therapeutic effect on serum andriol apolipoproteins and lipids in patients of coronary heart disease of older male. Chin Med Sci J. 1992 September; 7 (3) :137-